Triple Analysis: Pancreatic Cancer, Apoptosis and Protein Kinase Inhibitors

This triple analysis focuses on cancer drug development strategies in Pancreatic Cancer and by the two mechanism/target/effect areas of Apoptosis and Protein Kinase Inhibitors. Each of these three individual parts is evaluated according to standardized criteria in a five pillar pipeline drug assessment methodology to compare drug development strategies in oncology. This makes it easy to find and compare analysis not only within one single cancer focus area but also between different areas.

Below is a short synopsis of each part included in this report:

Part I: Pancreatic Cancer

The pancreatic cancer report part comprises defined and up to date development strategies for 213 pancreatic cancer drugs within the portfolio of 137 investigators, from Ceased to Marketed. This report part extensively analyses 171 identified targets of pancreatic cancer drugs, organized into 142 drug target profiles, and assesses them in pancreatic cancer.

This part is based on the following publication:

Portfolio Analytics in the Pancreatic Cancer Pipeline and Portfolio Planning - High Unmet Medical Need but Where to Target?

Part II: Apoptosis

The apoptotic cancer drug report part comprises defined and up to date development strategies for 234 drugs in oncology within the portfolio of 158 companies world-wide, from Ceased to Marketed. The report extensively analyses their 181 identified drug targets, organized into 157 drug target strategies, and assesses them in 69 cancer indications.

This part is based on the following publication:

Commercializing Apoptotic Drugs in Cancer: The Faster Route to Consider Your Options and Position of Others

Part III: Protein Kinase Inhibitors

The protein kinase report comprises defined and up to date development strategies for 409 protein kinase drugs (990 projects) within the portfolio of 160 investigators, from Ceased to Marketed. This report part extensively analyses 133 identified targets of protein kinase drugs, organized into 200 drug target strategies, and assesses them in 57 different cancer indications.

This part is based on the following publication:

Protein Kinase Therapeutics in Oncology - Where to Commercialize?

The report is written for you to understand and assess the impact of competitor entry and corresponding changes to development strategies for your own portfolio products. It helps teams to maximize molecule value by selecting optimal development plans and manage risk and uncertainty. The report serves as an external commercial advocate for pharmaceutical companies? pipeline and portfolio planning (PPP) in cancer by:

• Providing you with competitive input to the R&D organization to guide development of early product ideas and ensure efforts are aligned with business objectives
• Assisting you to make informed decisions in selecting cancer indications that are known to be appropriate for your drug?s properties
• Analyzing, correlating and integrating valuable data sources in order to provide accurate data for valuation of pipeline, in-licensing and new business opportunities
• Providing you with commercial analytic support for due diligence on in-licensing and acquisition opportunities
• Supporting development of integrative molecule, pathway and disease area strategies
• Integrating knowledge for you to consider the therapeutic target for the highest therapeutic outcome and return on investment

This report provides systems, analytical and strategic support both internally to PPP and to stakeholders across your own organization. The report will also be an important part of creating and implementing a market development plan for cancer drugs to insure that the optimal market conditions exist by the time the products are commercialized.

Source: http://c.moreover.com/click/here.pl?r5684239790&f=378

ucla basketball michelle obama booed at nascar polio cutler natalie wood christina aguilera tony stewart

CSRwire: Remembering '11: "What's the #business sense for #sustainability issues: #Water, #Energy, etc. and the context?" http://t.co/20KNt8Nq #csr

• Passer la navigation
• Twitter sur votre mobile ? Cliquez ici m.twitter.com!
• Passer cette ?tape
• Connexion

• Connexion
• Rejoignez Twitter !

Remembering '11: "What's the #business sense for #sustainability issues: #Water, #Energy, etc. and the context?" bit.ly/svbRRR #csr Il y a environ 1 heure via Visibli

CSRwire

Pied de page

• ? 2011 Twitter
• ? propos de nous
• Contact
• Blog
• Statut
• Ressources
• API
• Entreprises
• Aide
• Offres d'emploi
• Conditions
• Confidentialit?

Source: http://twitter.com/CSRwire/statuses/152943353196068864

grammys 2011 mike leach mike leach billy graham scion fr s elf on a shelf elf on a shelf

2011: A Year of Transition for Human Spaceflight (SPACE.com)

Human spaceflight turned 50 this year, but 2011 was less about drawing inspiration from the past than about transitioning to an uncertain future.

The year marking the 50th anniversary of Yuri Gagarin's historic first spaceflight also saw NASA ground its storied space shuttle fleet after three decades of service. The United States now has no vehicle capable of lofting astronauts to Earth orbit or beyond, although NASA and several private aerospace companies are working to change that.

2011 also saw NASA announce designs for a new spaceship and a heavy-lift rocket that will someday propel people toward deep-space destinations such as an asteroid or Mars.

"The year truly marks the beginning of a new era in the human exploration of our solar system," NASA administrator Charlie Bolden said on Dec. 20. [Vote: Biggest Spaceflight Stories of 2011]

It was also a year when China set an aggressive course toward establishing its own permanent manned presence in space.

No more space shuttle

The space shuttle era came to a close when Atlantis touched down at Florida's Kennedy Space Center on July 21, wrapping up its STS-135 mission.

NASA is now completely dependent on Russian Soyuz vehicles to ferry its astronauts to and from the International Space Station, paying $63 million per seat. This state of affairs troubles many observers, and the crash of Russia's Progress 44 supply vessel highlighted their concerns.

The unmanned Progress 44 launched on a cargo run to the space station Aug. 24 but didn't make it very far. It crashed in Siberia five minutes after liftoff, doomed by a problem with the third stage of its Soyuz rocket. Russia uses a similar version of the Soyuz to launch astronauts, so manned flights were suspended until the problem could be identified and fixed.

NASA has always intended its reliance on Russia to be temporary. The agency wants private American spacecraft ? operated by commercial companies such as SpaceX, Blue Origin, Sierra Nevada and Boeing ? to take over the Soyuz's orbital taxi role as soon as safely possible. [Top Private Spaceships Headed for Reality]

Just when that will happen is up in the air, however. NASA had pegged 2016 as a proposed start date, but recent cuts by Congress to the agency's Commercial Crew Development program are likely to push things back until 2017 at the earliest, officials said recently.

A new spaceship and rocket

In 2010, President Barack Obama instructed NASA to work toward getting astronauts to an asteroid by 2025 and to Mars by the mid-2030s. The shuttle program's end frees up some resources for such ambitious projects, and this year the agency laid out how it plans to reach these deep-space destinations.

In May, NASA announced that astronauts will ride in a spaceship called the Orion Multi-Purpose Crew Vehicle, which is based heavily on the Orion capsule concept from the agency's defunct moon-oriented Constellation program.

And in September, NASA unveiled the giant rocket that will blast Orion off the pad. The $10 billion Space Launch System (SLS) will loft 70 tons of payload in its early incarnations, and the space agency hopes to beef up the booster to handle 130 tons eventually. The plan is for the Orion-SLS combo to be operational by 2021.

Selecting a heavy-lift rocket design this year was a big deal, some analysts say, giving NASA and its human spaceflight program stability and direction.

"The decision to go ahead and develop the SLS is the thing that I think will have lasting impact" from this year, said space policy expert John Logsdon, professor emeritus at George Washington University.

Future not assured

The Obama administration has committed to the SLS, and the program has some powerful supporters in the Senate ? notably Kay Bailey Hutchison, R-Texas, and Bill Nelson, D-Fla. But long-term support for the heavy lifter is not guaranteed, Logsdon said.

The SLS also has its share of critics who regard it as too expensive. Further, Hutchison is retiring and Nelson faces a tough re-election fight in 2012. The president's re-election is also not assured, Logsdon noted.

So January 2013 could bring yet more transition to NASA.

"The question is whether there will be any champions of the current approach left in the Congress, and what a new president, if it's not Obama, would do," Logsdon told SPACE.com.

"Fragile" is a good word to describe the U.S. human spaceflight program at the end of 2011, Logsdon said. "It's on a path that is discernible, but there are all kinds of factors that could cause that path not to be followed."

China rising?

It was a year of transition for more than just NASA. China also made some big moves.

On Nov. 2, the nation successfully docked two unmanned spacecraft in orbit, a first for China. The mating of the Shenzhou 8 and Tiangong 1 vessels was designed to test technologies that China will use to build a space station in orbit. Beijing hopes to have a 66-ton manned station operational by 2020.

2012 is likely to see more progress toward this goal. China plans to launch two more docking missions, and officials have said that at least one of them will be manned.

You can follow SPACE.com senior writer Mike Wall on Twitter: @michaeldwall. Follow SPACE.com for the latest in space science and exploration news on Twitter @Spacedotcom and on Facebook.

Source: http://us.rd.yahoo.com/dailynews/rss/space/*http%3A//news.yahoo.com/s/space/20111228/sc_space/2011ayearoftransitionforhumanspaceflight

debra messing bowl games ayaan hirsi ali iowa caucus rachel uchitel strait of hormuz new years eve party ideas

How to plan your dream wedding in Colorado

Planning a wedding can be both incredibly exciting and a bit stressful, but with a little extra research it's easy to have the wedding of your dreams in the mountains of Colorado. Here are the top tips for getting married in Beaver Creek, Breckenridge, and other beautiful Colorado mountains towns.

1)????? Choose a venue that is meaningful to you: there are many gorgeous locations for a wedding in Colorado, so rather than trying to choose the most beautiful of such an abundance of splendor, consider selecting a place that has special meaning for you. For example, my friend Kelly felt that the mountains had a special meaning for her: "Ryan taught me how to snowboard at Breckenridge and we really got to know each other while we were snowboarding. During that time, I really realized how amazing the mountains are - it's something that a picture or words can't explain."

2)????? Balance meaning with vision: just because you're from a certain town or learned how to ski on a particular mountain doesn't mean you have to get married there if it doesn't feel right to you. Choose a venue that fits for a variety of reasons.

"We looked for a venue for 7 months and, in August of this year, we went to visit a few more venues in Beaver Creek, including the Ritz Carlton at Bachelor?Gulch," explained Kelly. "When we walked the lodge, I just felt like it was 'right.' It was cozy, relaxing, 'mountainy' and yet... it had that Colorado Lodge feel that we wanted -- and most of all, it was still classy and elegant."

3)????? Get a great photographer and videographer: saving those special memories is so important, this is perhaps the most essential area to not cut any corners. Find a great photographer who really specializes in capturing the moment rather than creating one, and consider also getting a videographer to really remember all the sights and sounds of the day.

4)????? Have a back-up plan for the weather: seriously, it's like bringing an umbrella so that it won't rain: your best guarantee that everything will work out fine. Even if you do need to go with your alternate plan and it's not exactly as beautiful as the great outdoors, it's much better than freezing in the rain or snow. "There is a great room with floor to ceiling windows, with views of the mountains," described Kelly. "ALMOST just as beautiful as the ceremony venue that we have planned, which is outside near the Ritz."

5)????? Have fun: obviously, the most important part of your wedding is for you to be present and enjoy the experience, which is such an incredible day in your life. If you feel like you're going to stress out about the details, don't feel bad about getting a wedding planner to help you relax.

"We were going to just do the wedding ourselves, but... after a few weeks of thinking about all of the stress that would come the week or so before the wedding, I had a breakdown in front of Ryan," said Kelly. "SO, we decided to hire a wedding planner for 'support' up until the week of the wedding. A week before the wedding, the wedding planner will take complete 'control' so we can have that week to be much more relaxed and less stressful."

Having a great venue, a fantastic photographer, a planner, and a good backup plan for the weather will all help you to relax and appreciate every moment. Enjoy the experience, and see you on the slopes!

-- Beth Hartman

?

Source: http://buzz.snow.com/channels/buzz_channels/snow-squad/b/weblog/archive/2011/12/25/how-to-plan-your-dream-wedding-in-colorado.aspx

scion fr s elf on a shelf elf on a shelf carrier iq carrier iq linda perry world aids day

India: Anna Hazare Hunger Strike Highlights Corruption

NEW DELHI -- An Indian activist began a three-day hunger strike Tuesday calling for Parliament to pass a tougher version of an anti-corruption bill than the one federal lawmakers were debating.

Anna Hazare began his fast in India's business capital, Mumbai, to protest what he calls a lack of teeth for an anti-corruption watchdog that the proposed bill would create.

Hazare has called the government's anti-graft legislation an attempt to fool the country without actually taking tough action to end rampant corruption that angers almost everyone.

His main complaint is that the proposed corruption ombudsman would not have authority over the country's top investigative agency, the Central Bureau of Investigation. He says the ombudsman position would be too weak without that authority.

In New Delhi, India's Parliament began its debate as junior parliamentary affairs minister V. Narayanasamy moved the bill in the powerful lower house, saying the legislation maintained the "fine balance" between the powers of the legislature, the judiciary and the executive branch.

Sushma Swaraj, the leader of the main opposition, right wing Bharatiya Janata Party, however, said that as the country waited for a "strong and effective" anti-corruption watchdog, the government was offering a bill that was "so full of holes and flaws that it has disappointed all of us."

Swaraj's party has thrown its weight behind Hazare's protest.

Hazare, who claims inspiration from Mohandas K. Gandhi, has called his protest against corruption India's second freedom struggle and has fasted three times already to garner support for his demands.

His previous public protests have drawn tens of thousands of people in a country where corruption is rampant and top officials are regularly embroiled in scandals even as hundreds of millions of people remain bitterly poor.

But critics say his populist campaign attempts to vilify all politicians and hold elected officials hostage.

Dozens of those critics came out on the streets Tuesday, waving black flags and shouting anti-Hazare slogans as Hazare's motorcade made its way to the Mumbai fairground where he was fasting.

Eight hours were set aside for the debate in Parliament's lower house on Tuesday. The government has said it will try to pass the legislation by Thursday.

'; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/2011/12/27/india-anna-hazare-hunger-strike_n_1170592.html

the descendants the descendants joe paterno lung cancer joe paterno lung cancer john tucker must die uk basketball iowa state

PFT: Heat 'should be on me,' Ryan says

Getty Images

Jets quarterback Mark Sanchez has taken a lot of criticism from fans and the media. But he says he has no doubt that within the locker room, he has unconditional support.

Asked at his press conference today if he is confident that everyone in the locker room supports him, Sanchez answered, ?Absolutely, no question.?

Sanchez offered a similar answer when asked if he thinks he has improved during his three-year NFL career.

?No question, absolutely,? Sanchez said. ?Whether it?s defensive recognition or clock management and stuff like that, understanding the offense and the system, I?m light years ahead, so it?s been a great run so far and we?re not done yet. Hopefully, we?ll get a win and see what happens.?

But watching Sanchez, it?s hard to see how he has really improved in terms of his defensive recognition and clock management. He still makes too many mental mistakes, and he wastes timeouts too often to claim he has improved at clock management.

Ball security is also a huge problem for Sanchez, who fumbled 10 times in his rookie year, nine times last year and has fumbled 10 times this year. Those ball security problems were largely overlooked in his first two seasons because the Jets recovered seven of his 10 fumbles his rookie year and eight of his nine fumbles his second year. But this year the Jets have only recovered two of Sanchez?s 10 fumbles, and the problem of a quarterback who puts the ball on the ground too much has become more apparent.

Ultimately, Sanchez probably got too much credit when the Jets got to back-to-back AFC Championship Games in his first two years, and now he?s probably getting too much blame for the Jets likely missing the playoffs.

?We went to the AFC Championship two years in a row, so there is only one more step to make really, win that game and then go win the Super Bowl,? Sanchez said. ?With those expectations, that?s fine. When things don?t go right, people are going to immediately question me.?

No one said playing quarterback for the New York Jets would be easy.

Source: http://profootballtalk.nbcsports.com/2011/12/28/rex-ryan-heat-should-be-on-me-not-sanchez-or-schottenheimer/related/

rosie o donnell st nicholas st nicholas mindy mccready mindy mccready cliff harris cliff harris

HTC unlocks all Android bootloaders from smartphones launched after September 20...

Sorry, Readability was unable to parse this page for content.

Source: http://www.facebook.com/tmonews/posts/202314766525686

strait of hormuz phish mega millions dog the bounty hunter kawasaki disease rachel uchitel golden state warriors